The Applied Physiology Laboratory (APL), 101 Robinson Center, contains modern applied physiology equipment used to assess a variety of physiological, biochemical and molecular variables. A wide range of human experiments are performed and analyzed in the APL. The major research emphasis of the APL is on the physiological processes that transpire with heart failure and aging from the whole organism to the sub-cellular level. Please visit the other links to this site to gain more information on the specific studies ongoing and to obtain information on the APL staff.
The University of Kansas Applied Physiology Laboratory is a freestanding facility with 4,500 square feet of research and office space. The Applied Physiology Laboratory houses a biochemistry area, a molecular biology area, a blood draw and muscle biopsy procedures room, an exercise testing area, a histochemical area, and various areas for exercise/metabolic testing.
The Exercise Physiology Lab is located in the main portion of the Human Performance Laboratories. The Lab has an assortment of “cutting-edge” equipment to provide us with the most precise research methods possible. Some of our featured equipment include: Med Graphics Metabolic Cart, Treadmill, Lode cycle ergometer, Wingate testing software, Environmental chamber, Hydrostatic weighing tank, a strength dynamomter, a procedure room, Histochemistry room including a Microtome cryostat, and a Digital Microscope.
Our Biochemistry Lab features a water purifier, storage area for chemicals, a vertical gel electrophoresis unit, ventilation hood, one refrigerator/freezer, one Ultra-low freezer, a Cryogenic Storage System, and an ice machine.
Our Clinical Fitness Lab is used mainly in a classroom setting and features a Sensor Medics 2900 metabolic cart, 6 Monarch bikes, 7 treadmills, and 5 ECG interpreters.
The Molecular/Cell Biology Lab features a Real Time PCR, precision liquid handling system, a Biophotometer, a Universal Microplate Reader with washer and shaler incubator, a horizontal gel system, a Kodak gel imaging system, one Ultra-low freezer and various balances, pH meters, vortexs, etc.
The research direction at the Applied Physiology Laboratory is primarily focused on skeletal muscle physiology. Conditions such as aging and many diseases elicit significant muscle loss. Thus, it is our goal to investigate the underlying mechanisms and etiology of muscle atrophy and hypertrophy with the long-term intent of developing a successful countermeasure strategy to muscle wasting.
Currently, the Applied Physiology laboratory is conducting several different research studies:
Creer, A., P. Gallagher, D. Slivka, B. Jemiolo, W. Fink, S. Trappe. Influence of pre-exercise muscle glycogen levels on mitogenic responses to resistance exercise. J Appl Physiol , 99: 950–956, 2005.
Gallagher, P., M. Harber, A. Creer, S. Mazzetti, T. Trappe, B. Alkner, P. Tesch, S. Trappe. Effects of a resistance-training countermeasure to prolonged bedrest on single fiber myosin heavy chain distribution. Acta Physiol Scand , 185:61-69, 2005.
Godard, M. and P. Gallagher. Potential mechanisms for skeletal muscle wasting. American College of Sports Medicin, Central State Regional Meeting. Kansas City , Missouri (October 2004).
Trappe, S, T. Trappe, P. Gallagher, M. Harber, B. Alkner, P. Tesch. Human single muscle fibre function with 84 day bed-rest and resistance exercise. J Physiol (Lond ), 557:501-513, 2004.
Trappe, S., P. Gallagher, M. Harber, J. Carrithers, and T. Trappe. Aging Human Skeletal Muscle: Single Muscle Fiber Contractile Properties. J Physiol (Lond ), 552: 47-58, 2003.
Godard, M.P., P.M. Gallagher, U. Raue, and S.W. Trappe. Alterations in single muscle fiber calcium sensitivity with resistance training in older women. Pflugers Archive - European Journal of Physiology, 444: 419-425, 2002 .
Applied Physiology Lab
Room 101 Robinson
1301 Sunnyside Drive
University of Kansas
Lawrence , KS 66045 -2378
From K-10
• Follow 23 rd st. west until you reach Naismith Dr .
• Turn right onto Naismith Dr .
• Turn right onto Sunnyside Ave.
• Park in the parking lot to your right in a metered parking spot.
From I-70
• Exit 202 toward US-59 S/West Lawrence
• Take the US-59 South ramp and Merge onto Iowa St.
• Take a left on 23 rd St .
• Take a left on Naismith Dr .
• Turn right onto Sunnyside Ave.
• Park in the parking lot to your right in a metered parking spot.
*For driving directions from a specific location use mapquest driving directions located: Driving Directions
Philip Gallager, Ph.D.
Assistant Professor of Applied Physiology
Michael Wacker mwacker@ku.edu
Post-Doctoral Fellow
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