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KU School of Education Home » Labs and Clinics » Applied Physiology Lab

Applied Physiology Lab

The Applied Physiology Laboratory (APL), 101 Robinson Center, contains modern applied physiology equipment used to assess a variety of physiological, biochemical and molecular variables. A wide range of human experiments are performed and analyzed in the APL. The major research emphasis of the APL is on the physiological processes that transpire with heart failure and aging from the whole organism to the sub-cellular level. Please visit the other links to this site to gain more information on the specific studies ongoing and to obtain information on the APL staff.

Applied Physiology Lab Facilities

Exercise Physiology LabThe University of Kansas Applied Physiology Laboratory is a freestanding facility with 4,500 square feet of research and office space. The Applied Physiology Laboratory houses a biochemistry area, a molecular biology area, a blood draw and muscle biopsy procedures room, an exercise testing area, a histochemical area, and various areas for exercise/metabolic testing.


Exercise Physiology Area

Biomechanics LabThe Exercise Physiology Lab is located in the main portion of the Human Performance Laboratories. The Lab has an assortment of “cutting-edge” equipment to provide us with the most precise research methods possible. Some of our featured equipment include: Med Graphics Metabolic Cart, Treadmill, Lode cycle ergometer, Wingate testing software, Environmental chamber, Hydrostatic weighing tank, a strength dynamomter, a procedure room, Histochemistry room including a Microtome cryostat, and a Digital Microscope.


Biochemistry Area

Proceedures RoomOur Biochemistry Lab features a water purifier, storage area for chemicals, a vertical gel electrophoresis unit, ventilation hood, one refrigerator/freezer, one Ultra-low freezer, a Cryogenic Storage System, and an ice machine.


Clinical Testing/Assessment Area

Histochemisty LabOur Clinical Fitness Lab is used mainly in a classroom setting and features a Sensor Medics 2900 metabolic cart, 6 Monarch bikes, 7 treadmills, and 5 ECG interpreters.


Molecular/Cell Biology Area

Molecular Biology LabThe Molecular/Cell Biology Lab features a Real Time PCR, precision liquid handling system, a Biophotometer, a Universal Microplate Reader with washer and shaler incubator, a horizontal gel system, a Kodak gel imaging system, one Ultra-low freezer and various balances, pH meters, vortexs, etc.


Applied Physiology Lab Research

Primary Focus

The research direction at the Applied Physiology Laboratory is primarily focused on skeletal muscle physiology. Conditions such as aging and many diseases elicit significant muscle loss. Thus, it is our goal to investigate the underlying mechanisms and etiology of muscle atrophy and hypertrophy with the long-term intent of developing a successful countermeasure strategy to muscle wasting.

Current Projects

Currently, the Applied Physiology Laboratory is conducting several different research studies:

  1. Examining the role that heat-shock proteins play in preventing muscle damage and atrophy.
  2. The interaction of forskolin and insulin on intracellular signaling pathways in skeletal muscle.
  3. Effects of exercise and proteins or amino acid supplementation on markers of muscle growth.
  4. Examining the role that apoptosis and the ubiquitin proteosome pathway has on aging skeletal muscle.

Selected Publications & Presentations

  1. Richmond, S, C Touchberry, P Gallagher. Forskolin attenuates the action of insulin on the Akt/mTOR pathway in human skeletal muscle. Appl Physiol Nutri Metab, (in press).

  2. Trappe, S, D Costill, P Gallagher, A Creer, J Peters, H Evans, D Riley, R Fitts. Exercise in Space: Skeletal muscle after 6 months aboard the international space station. J Appl Physiol, 106: 1159-1168, 2009.

  3. Wacker, M, M Tehel, P Gallagher. Technique for quantitative RT-PCR analysis directly from single muscle fibers. J Appl Physiol, 105: 308-15, 2008.

  4. Touchberry, C, T Le, S Richmond, M Prewitt, D Beck, D Carr, P Vardiman, P Gallagher. Diathermy treatment increases heat shock protein expression in female, but not male skeletal muscle.  Eur J Appl Physiol, 102:319-23, 2008.

  5. Gallagher, P, M Harber, A Creer, S Mazzetti, T Trappe, B Alkner, P Tesch, S Trappe. Effects of 84-days of bedrest and resistance training on single muscle fibre myosin heavy chain distribution in human vastus lateralis and soleus muscles. Acta Physiol Scand, 185:61-69, 2005.

Applied Physiology Lab Directions

Applied Physiology Lab

Room 101 Robinson

1301 Sunnyside Drive
University of Kansas
Lawrence , KS 66045 -2378

From K-10

• Follow 23 rd st. west until you reach Naismith Dr .

• Turn right onto Naismith Dr .

• Turn right onto Sunnyside Ave.

• Park in the parking lot to your right in a metered parking spot.

From I-70

• Exit 202 toward US-59 S/West Lawrence

• Take the US-59 South ramp and Merge onto Iowa St.

• Take a left on 23 rd St .

• Take a left on Naismith Dr .

• Turn right onto Sunnyside Ave.

• Park in the parking lot to your right in a metered parking spot.

 

*For driving directions from a specific location use mapquest driving directions located: Driving Directions


Applied Physiology Lab Faculty and Staff

Laboratory Director

Phil Gallager
Philip Gallager
, Ph.D.
Assistant Professor of Applied Physiology

 


Contact Us

Applied Physiology Lab

Phone: (785)864-0773

Fax: (785)864-3343

e-mail: exercise@ku.edu


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